GrippeEspagneV1, Main, Exploration, bibRecord, 000266

Early non-invasive ventilation treatment for severe influenza pneumonia.

Identifieur interne : 000266 ( Main/Exploration ); précédent : 000265; suivant : 000267

Early non-invasive ventilation treatment for severe influenza pneumonia.

Auteurs : J R Masclans [Espagne] ; M. Pérez ; J. Almirall ; L. Lorente ; A. Marqués ; L. Socias ; L. Vidaur ; J. Rello

Source :

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2013.

RBID : pubmed:22404211

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Espagne (MeSH), Femelle (MeSH), Grippe humaine (complications), Humains (MeSH), Indice de gravité de la maladie (MeSH), Mâle (MeSH), Pneumopathie virale (thérapie), Poumon (anatomopathologie), Poumon (imagerie diagnostique), Radiographie (MeSH), Résultat thérapeutique (MeSH), Ventilation non effractive (méthodes), Études prospectives (MeSH).
MESH :
- anatomopathologie : Poumon.
- imagerie diagnostique : Poumon.
- méthodes : Ventilation non effractive.
- thérapie : Pneumopathie virale.
- complications : Adulte, Adulte d'âge moyen, Espagne, Femelle, Grippe humaine, Humains, Indice de gravité de la maladie, Mâle, Radiographie, Résultat thérapeutique, Études prospectives.

English descriptors

KwdEn :
- Adult (MeSH), Female (MeSH), Humans (MeSH), Influenza, Human (complications), Lung (diagnostic imaging), Lung (pathology), Male (MeSH), Middle Aged (MeSH), Noninvasive Ventilation (methods), Pneumonia, Viral (therapy), Prospective Studies (MeSH), Radiography (MeSH), Severity of Illness Index (MeSH), Spain (MeSH), Treatment Outcome (MeSH).
MESH :
- complications : Influenza, Human.
- diagnostic imaging : Lung.
- methods : Noninvasive Ventilation.
- pathology : Lung.
- therapy : Pneumonia, Viral.
- Adult, Female, Humans, Male, Middle Aged, Prospective Studies, Radiography, Severity of Illness Index, Spain, Treatment Outcome.

Abstract

The role of non-invasive ventilation (NIV) in acute respiratory failure caused by viral pneumonia remains controversial. Our objective was to evaluate the use of NIV in a cohort of (H1N1)v pneumonia. Usefulness and success of NIV were assessed in a prospective, observational registry of patients with influenza A (H1N1) virus pneumonia in 148 Spanish intensive care units (ICUs) in 2009-10. Significant variables for NIV success were included in a multivariate analysis. In all, 685 patients with confirmed influenza A (H1N1)v viral pneumonia were admitted to participating ICUs; 489 were ventilated, 177 with NIV. The NIV was successful in 72 patients (40.7%), the rest required intubation. Low Acute Physiology and Chronic Health Evaluation (APACHE) II, low Sequential Organ Failure Assessment (SOFA) and absence of renal failure were associated with NIV success. Success of NIV was independently associated with fewer than two chest X-ray quadrant opacities (OR 3.5) and no vasopressor requirement (OR 8.1). However, among patients with two or more quadrant opacities, a SOFA score ≤7 presented a higher success rate than those with SOFA score >7 (OR 10.7). Patients in whom NIV was successful required shorter ventilation time, shorter ICU stay and hospital stay than NIV failure. In patients in whom NIV failed, the delay in intubation did not increase mortality (26.5% versus 24.2%). Clinicians used NIV in 25.8% of influenza A (H1N1)v viral pneumonia admitted to ICU, and treatment was effective in 40.6% of them. NIV success was associated with shorter hospital stay and mortality similar to non-ventilated patients. NIV failure was associated with a mortality similar to those who were intubated from the start.

DOI: 10.1111/j.1469-0691.2012.03797.x
PubMed: 22404211
PubMed Central: PMC7128378

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Lung (diagnostic imaging)</term>
<term>Lung (pathology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
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<term>Treatment Outcome (MeSH)</term>
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<term>Grippe humaine (complications)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
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<front><div type="abstract" xml:lang="en">The role of non-invasive ventilation (NIV) in acute respiratory failure caused by viral pneumonia remains controversial. Our objective was to evaluate the use of NIV in a cohort of (H1N1)v pneumonia. Usefulness and success of NIV were assessed in a prospective, observational registry of patients with influenza A (H1N1) virus pneumonia in 148 Spanish intensive care units (ICUs) in 2009-10. Significant variables for NIV success were included in a multivariate analysis. In all, 685 patients with confirmed influenza A (H1N1)v viral pneumonia were admitted to participating ICUs; 489 were ventilated, 177 with NIV. The NIV was successful in 72 patients (40.7%), the rest required intubation. Low Acute Physiology and Chronic Health Evaluation (APACHE) II, low Sequential Organ Failure Assessment (SOFA) and absence of renal failure were associated with NIV success. Success of NIV was independently associated with fewer than two chest X-ray quadrant opacities (OR 3.5) and no vasopressor requirement (OR 8.1). However, among patients with two or more quadrant opacities, a SOFA score ≤7 presented a higher success rate than those with SOFA score >7 (OR 10.7). Patients in whom NIV was successful required shorter ventilation time, shorter ICU stay and hospital stay than NIV failure. In patients in whom NIV failed, the delay in intubation did not increase mortality (26.5% versus 24.2%). Clinicians used NIV in 25.8% of influenza A (H1N1)v viral pneumonia admitted to ICU, and treatment was effective in 40.6% of them. NIV success was associated with shorter hospital stay and mortality similar to non-ventilated patients. NIV failure was associated with a mortality similar to those who were intubated from the start.</div>
</front>
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<Abstract><AbstractText>The role of non-invasive ventilation (NIV) in acute respiratory failure caused by viral pneumonia remains controversial. Our objective was to evaluate the use of NIV in a cohort of (H1N1)v pneumonia. Usefulness and success of NIV were assessed in a prospective, observational registry of patients with influenza A (H1N1) virus pneumonia in 148 Spanish intensive care units (ICUs) in 2009-10. Significant variables for NIV success were included in a multivariate analysis. In all, 685 patients with confirmed influenza A (H1N1)v viral pneumonia were admitted to participating ICUs; 489 were ventilated, 177 with NIV. The NIV was successful in 72 patients (40.7%), the rest required intubation. Low Acute Physiology and Chronic Health Evaluation (APACHE) II, low Sequential Organ Failure Assessment (SOFA) and absence of renal failure were associated with NIV success. Success of NIV was independently associated with fewer than two chest X-ray quadrant opacities (OR 3.5) and no vasopressor requirement (OR 8.1). However, among patients with two or more quadrant opacities, a SOFA score ≤7 presented a higher success rate than those with SOFA score >7 (OR 10.7). Patients in whom NIV was successful required shorter ventilation time, shorter ICU stay and hospital stay than NIV failure. In patients in whom NIV failed, the delay in intubation did not increase mortality (26.5% versus 24.2%). Clinicians used NIV in 25.8% of influenza A (H1N1)v viral pneumonia admitted to ICU, and treatment was effective in 40.6% of them. NIV success was associated with shorter hospital stay and mortality similar to non-ventilated patients. NIV failure was associated with a mortality similar to those who were intubated from the start.</AbstractText>
<CopyrightInformation>© 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.</CopyrightInformation>
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<ForeName>J R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Pérez</LastName>
<ForeName>M</ForeName>
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<Author ValidYN="Y"><LastName>Almirall</LastName>
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<Author ValidYN="Y"><LastName>Lorente</LastName>
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<Initials>A</Initials>
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<Author ValidYN="Y"><LastName>Socias</LastName>
<ForeName>L</ForeName>
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<Author ValidYN="Y"><LastName>Vidaur</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
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<Author ValidYN="Y"><LastName>Rello</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
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<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
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<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
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<ForeName>Pedro</ForeName>
<Initials>P</Initials>
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<Investigator ValidYN="Y"><LastName>Martins</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carbayo</LastName>
<ForeName>Cecilia</ForeName>
<Initials>C</Initials>
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<Investigator ValidYN="Y"><LastName>Robles-Musso</LastName>
<ForeName>Emilio</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cárdenas</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
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<Investigator ValidYN="Y"><LastName>Fierro</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
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<Investigator ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Dolores Ocaña</ForeName>
<Initials>DO</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sierra</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
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<Investigator ValidYN="Y"><LastName>Huertos</LastName>
<ForeName>Ma Jesús</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guerrero</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sofía</LastName>
<ForeName>Reina</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Márquez</LastName>
<ForeName>Enrique</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rodríguez-Carvajal</LastName>
<ForeName>Manuel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jiménez</LastName>
<ForeName>Juan Ramón</ForeName>
<Initials>JR</Initials>
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<Investigator ValidYN="Y"><LastName>Jareño</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
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<Investigator ValidYN="Y"><LastName>Estella</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pomares</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ballesteros</LastName>
<ForeName>José Luis</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Yolanda</ForeName>
<Initials>Y</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lobato</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Prieto</LastName>
<ForeName>José F</ForeName>
<Initials>JF</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Albofedo-Sánchez</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martínez</LastName>
<ForeName>Pilar</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Castellanos</LastName>
<ForeName>Miguel Angel Díaz</ForeName>
<Initials>MA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sevilla</LastName>
<ForeName>Guillermo</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garnacho-Montero</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hinojosa</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Esteban</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Loza</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>León</LastName>
<ForeName>Cristóbal</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arenzana</LastName>
<ForeName>Angel</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ocaña</LastName>
<ForeName>Dolores</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Navarrete</LastName>
<ForeName>Inés</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Beryanaki</LastName>
<ForeName>Medhi Zaheri</ForeName>
<Initials>MZ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sánchez</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Avellanas</LastName>
<ForeName>Manuel Luis</ForeName>
<Initials>ML</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lacueva</LastName>
<ForeName>M I Marquina</ForeName>
<Initials>MI</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Luque</LastName>
<ForeName>Pilar</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blesa</LastName>
<ForeName>Lozano</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Servet</LastName>
<ForeName>Miquel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Montón</LastName>
<ForeName>Jose Ma</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Polanco</LastName>
<ForeName>Obispo</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Regil</LastName>
<ForeName>Paloma Dorado</ForeName>
<Initials>PD</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Villanova</LastName>
<ForeName>Royo</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Iglesias</LastName>
<ForeName>Lisardo</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González</LastName>
<ForeName>Carmen Pascual</ForeName>
<Initials>CP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García-Rodríguez</LastName>
<ForeName>Águeda</ForeName>
<Initials>Á</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Socias</LastName>
<ForeName>Lorenzo</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ibánez</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Borges-Sa</LastName>
<ForeName>Marcío</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Socias</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Del Castillo</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marcos</LastName>
<ForeName>Ricard Jordà</ForeName>
<Initials>RJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bonell</LastName>
<ForeName>José M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Amestarán</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ruiz-Santana</LastName>
<ForeName>Sergio</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Díaz</LastName>
<ForeName>Juan José</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ferrer</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sole-Violan</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Molina</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hernández</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Trujillo</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Regalado</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lorente</LastName>
<ForeName>Leonardo</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martín</LastName>
<ForeName>Mar</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martínez</LastName>
<ForeName>Sergio</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cáceres</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Suberviola</LastName>
<ForeName>Borja</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ugarte</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García-López</LastName>
<ForeName>Fernando</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alonso</LastName>
<ForeName>Angel Álvaro</ForeName>
<Initials>AÁ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pasilla</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Grande</LastName>
<ForeName>Luisa Gómez</ForeName>
<Initials>LG</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Albaya</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Canabal</LastName>
<ForeName>Alfonso</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marina</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Simón</LastName>
<ForeName>Almudena</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Añón</LastName>
<ForeName>José María</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Messa</LastName>
<ForeName>B López</ForeName>
<Initials>BL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pueyo</LastName>
<ForeName>Ma Jesús López</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ferreras</LastName>
<ForeName>Zulema</ForeName>
<Initials>Z</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Macias</LastName>
<ForeName>Santiago</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Berezo</LastName>
<ForeName>José Ángel</ForeName>
<Initials>JÁ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Varela</LastName>
<ForeName>Jesús Blanco</ForeName>
<Initials>JB</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ojeda A</LastName>
<ForeName>Andaluz</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Terrero</LastName>
<ForeName>Antonio Álvarez</ForeName>
<Initials>AÁ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ezpeleta</LastName>
<ForeName>Fabiola Tena</ForeName>
<Initials>FT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Paez</LastName>
<ForeName>Zulema</ForeName>
<Initials>Z</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García</LastName>
<ForeName>Álvaro</ForeName>
<Initials>Á</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vega</LastName>
<ForeName>Virgen</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Catalán</LastName>
<ForeName>Rosa Ma</ForeName>
<Initials>RM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ferrer</LastName>
<ForeName>Miquel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Torres</LastName>
<ForeName>Antoni</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Barbadillo</LastName>
<ForeName>Sandra</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cabré</LastName>
<ForeName>Lluís</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rovira</LastName>
<ForeName>Assumpta</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Álvarez-Lerma</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vázquez</LastName>
<ForeName>Antonia</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nolla</LastName>
<ForeName>Joan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cervelló</LastName>
<ForeName>Joaquim Ramón</ForeName>
<Initials>JR</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mañéz</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ballús</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Granada</LastName>
<ForeName>Rosa Ma</ForeName>
<Initials>RM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vallés</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ortíz</LastName>
<ForeName>Marta</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guía</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arméstar</LastName>
<ForeName>Fernando</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Páez</LastName>
<ForeName>Joaquim</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Almirall</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Balanzo</LastName>
<ForeName>Xavier</ForeName>
<Initials>X</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arnau</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Laborda</LastName>
<ForeName>Cesar</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Souto</LastName>
<ForeName>Jessica</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Masclans</LastName>
<ForeName>J R</ForeName>
<Initials>JR</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Llopart</LastName>
<ForeName>Lluis</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sanchez</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Catalán</LastName>
<ForeName>Iñaki</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Déu</LastName>
<ForeName>Sant Joan</ForeName>
<Initials>SJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sirvent</LastName>
<ForeName>Josep Ma</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ferri</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Arbina</LastName>
<ForeName>Nerea López</ForeName>
<Initials>NL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Trueta</LastName>
<ForeName>Josep</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Badía</LastName>
<ForeName>Mariona</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Valverdú-Vidal</LastName>
<ForeName>Montserrat</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Barcenilla</LastName>
<ForeName>Fernando</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Vilanova</LastName>
<ForeName>Arnau</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Magret</LastName>
<ForeName>Mònica</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Esteban</LastName>
<ForeName>M F</ForeName>
<Initials>MF</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Luna</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nava</LastName>
<ForeName>Juan Ma</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Molina</LastName>
<ForeName>J González</ForeName>
<Initials>JG</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Josic</LastName>
<ForeName>Zoran</ForeName>
<Initials>Z</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gurri</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rello</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rodríguez</LastName>
<ForeName>Alejandro</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lisboa</LastName>
<ForeName>Thiago</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Mendoza</LastName>
<ForeName>Diego</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Parra</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garcia</LastName>
<ForeName>Evelyn</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>XXIII</LastName>
<ForeName>Joan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Díaz</LastName>
<ForeName>Rosa María</ForeName>
<Initials>RM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mesalles</LastName>
<ForeName>Eduard</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>José</LastName>
<ForeName>Juliá-Narváez</ForeName>
<Initials>JN</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cristina</LastName>
<ForeName>Infanta</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernández-Zapata</LastName>
<ForeName>Alberto</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Recio</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arrascaeta</LastName>
<ForeName>Abilio</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García-Ramos</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gallego</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bueno</LastName>
<ForeName>Fernándo</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Díaz</LastName>
<ForeName>Mercedes</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cordero</LastName>
<ForeName>Lourdes</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pastor</LastName>
<ForeName>José A</ForeName>
<Initials>JA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Álvarez-Rocha</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Coruña</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vila</LastName>
<ForeName>Dolores</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lamas</LastName>
<ForeName>Ana Díaz</ForeName>
<Initials>AD</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blanco Pérez</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ortiz Piquer</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Merayo</LastName>
<ForeName>Eleuterio</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>López-Ciudad</LastName>
<ForeName>Victor Jose</ForeName>
<Initials>VJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cortez</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vilaboy</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Saborido</LastName>
<ForeName>Eva Maria</ForeName>
<Initials>EM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González</LastName>
<ForeName>Raul José</ForeName>
<Initials>RJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>López</LastName>
<ForeName>Ana María</ForeName>
<Initials>AM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Canabal</LastName>
<ForeName>Julio</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ferres</LastName>
<ForeName>Enrique</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Monzón</LastName>
<ForeName>José Luis</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Goñi</LastName>
<ForeName>Félix</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Del Nogal Sáez</LastName>
<ForeName>Frutos</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Navalpotro</LastName>
<ForeName>M Blasco</ForeName>
<Initials>MB</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ochoa</LastName>
<ForeName>Severo</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García-Torrejón</LastName>
<ForeName>Ma   Carmen</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pérez-Calvo</LastName>
<ForeName>César</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>López</LastName>
<ForeName>Diego</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arnaiz</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sánchez-Alonso</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Velayos</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>del Río</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González</LastName>
<ForeName>Miguel Ángel</ForeName>
<Initials>MÁ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martín</LastName>
<ForeName>María Cruz</ForeName>
<Initials>MC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Molina</LastName>
<ForeName>José Ma</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Montejo</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Catalán</LastName>
<ForeName>Mercedes</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Albert</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Pablo</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guerrero</LastName>
<ForeName>José Eugenio</ForeName>
<Initials>JE</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Peyrat</LastName>
<ForeName>Jaime Benitez</ForeName>
<Initials>JB</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marañón</LastName>
<ForeName>Gregorio</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cerdá</LastName>
<ForeName>Enrique</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alvarez</LastName>
<ForeName>Manuel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pey</LastName>
<ForeName>Carlos</ForeName>
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Early non-invasive ventilation treatment for severe influenza pneumonia.

Early non-invasive ventilation treatment for severe influenza pneumonia.

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